Search results for "Single copy"
showing 3 items of 3 documents
Risk estimation in localized unresectable single copy MYCN neuroblastoma by the status of chromosomes 1p and 11q
2006
In localized neuroblastoma, the identification of patients requiring intensive treatment is still difficult. We retrospectively analyzed data of 280 single copy MYCN stage 2 and 3 neuroblastoma patients with gross residual tumor after initial surgery. The 3-year-event free survival of the total group was 83+/-2%, and 3-year-overall survival was 92+/-2%. Patients < or=1.5 years had a better outcome than older children. Deletions/imbalances of chromosome 1p were found in 9/90 patients and were associated with a higher event rate but not with a higher death rate. Aberrations of chromosome 11q in 14/91 patients were correlated with a higher event and death rate. Multivariate analysis identified…
Genome-wide promoter methylation analysis in neuroblastoma identifies prognostic methylation biomarkers.
2012
Background: Accurate outcome prediction in neuroblastoma, which is necessary to enable the optimal choice of risk-related therapy, remains a challenge. To improve neuroblastoma patient stratification, this study aimed to identify prognostic tumor DNA methylation biomarkers.Results: To identify genes silenced by promoter methylation, we first applied two independent genome-wide methylation screening methodologies to eight neuroblastoma cell lines. Specifically, we used re-expression profiling upon 5-aza-2'-deoxycytidine (DAC) treatment and massively parallel sequencing after capturing with a methyl-CpG-binding domain (MBD-seq). Putative methylation markers were selected from DAC-upregulated …
Remarques diplomàtiques al voltant del document de creació de la Biblioteca Reial de Poblet (Poblet, 20 d'agost de 1380)
1999
This paper analyzes a copy of a document dated at the Monastery of Poblet, 20th August, 1380. It states that the King Pedro el Ceremonioso was in the process of establishing a library in it. The absence of the original document as well as the existence of a single copy and several textual irregularities required a diplomatic analysis of the text, so that it could be adequately used as a historical source.[fr] Le présent article analyse la copie du document daté au Monastère de Poblet le 20 août 1380, selon lequel le roi Pedro el Ceremonioso avrait fondé une bibliothèque à ce monastère. L'absence du document original, Texistence d'une seule copie, ainsi comme la présence de certes irrégulari…